Whole-genome sequencing (WGS) data for the iSCORE-PD isogenic hESC clone collection. 150bp paired-end WGS was performed on Illumina NovaSeq X for 49 mutant clones across 11 PD-linked genes, 12 control lines (8 engineered wild-type subclones, 3 WIBR3 subclones, and the WIBR3 parental line), and 5 DJ1/PARK7 heterozygous clones. Variants were called using DeepVariant and jointly genotyped with GLnexus v1.4.1, producing per-chromosome VCF files aligned to GRCh38. ASAP Team: Rio Dataset Name: rio-hesc-wgs-iscore-pd-genotyping-and-snps, v1.0 Principal Investigator: Donald Rio Co-Principal Investigator: Frank Soldner; Dirk Hockemeyer; Helen Bateup Contributors: Busquets, Oriol; Li, Hanqin; Syed, Khaja Mohieddin; Alvarez-Jerez, Pilar; Dunnack, Jesse; Lo Bu, Riana; Verma, Yogendra; Pangilinan, Gabriella R.; Martin, Annika; Straub, Jannes; Du, YuXin; Simon, Vivien M.; Poser, Steven; Bush, Zipporiah; Diaz, Jessica; Sahagun, Atehsa; Gao, Jianpu; Hong, Samantha; Hernandez, Dena G.; Levine, Kristin S.; Pochet, Nathalie; Booth, Ezgi O.; Blanchette, Marco; Bateup, Helen S.; Rio, Donald C.; Blauwendraat, Cornelis; Hockemeyer, Dirk; Soldner, Frank Sample Summary: Resources and Additional...
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iSCORE-PD: Whole-genome sequencing and variant calling of isogenic hESC clones and controls is published on ASAP CRN Cloud.